ALMS1-Deficient Fibroblasts Over-Express Extra-Cellular Matrix Components, Display Cell Cycle Delay and Are Resistant to Apoptosis

Alström Syndrome (ALMS) is a rare genetic disorder (483 living cases), characterized by many clinical manifestations, including blindness, obesity, type 2 diabetes and cardiomyopathy. ALMS is caused by mutations in the ALMS1 gene, encoding for a large protein with implicated roles in ciliary functio...

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Detalles Bibliográficos
Autores principales: Zulato, Elisabetta, Favaretto, Francesca, Veronese, Caterina, Campanaro, Stefano, Marshall, Jan D., Romano, Sara, Cabrelle, Anna, Collin, Gayle B., Zavan, Barbara, Belloni, Anna S., Rampazzo, Enrica, Naggert, Jürgen K., Abatangelo, Giovanni, Sicolo, Nicola, Maffei, Pietro, Milan, Gabriella, Vettor, Roberto
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082548/
https://www.ncbi.nlm.nih.gov/pubmed/21541333
http://dx.doi.org/10.1371/journal.pone.0019081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082548/
https://www.ncbi.nlm.nih.gov/pubmed/21541333
http://dx.doi.org/10.1371/journal.pone.0019081

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