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Modelling and simulation as research tools in paediatric drug development
PURPOSE: Although practical and ethical constraints impose special requirements for the evaluation of treatment safety and efficacy in children, the main issue remains the empirical basis for patient stratification and dose selection at the early stage of the development of new chemical and biologic...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082698/ https://www.ncbi.nlm.nih.gov/pubmed/21246352 http://dx.doi.org/10.1007/s00228-010-0974-3 |