Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA

Various chemical modifications are currently being evaluated for improving the efficacy of short interfering RNA (siRNA) duplexes as antisense agents for gene silencing in vivo. Among the 2′-ribose modifications assessed to date, 2′deoxy-2′-fluoro-RNA (2′-F-RNA) has unique properties for RNA interfe...

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Detalles Bibliográficos
Autores principales: Pallan, Pradeep S., Greene, Emily M., Jicman, Paul Andrei, Pandey, Rajendra K., Manoharan, Muthiah, Rozners, Eriks, Egli, Martin
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082899/
https://www.ncbi.nlm.nih.gov/pubmed/21183463
http://dx.doi.org/10.1093/nar/gkq1270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082899/
https://www.ncbi.nlm.nih.gov/pubmed/21183463
http://dx.doi.org/10.1093/nar/gkq1270

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