Molecular Mechanism Underlying Phosphatidylinositol 4,5-Bisphosphate-induced Inhibition of SpIH Channels

Many ion channels have been shown to be regulated by the membrane signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)). Here, we demonstrate that the binding of PIP(2) to SpIH, a sea urchin hyperpolarization-activated cyclic nucleotide-gated ion channel (HCN), has a dual effect: pot...

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Detalles Bibliográficos
Autores principales: Flynn, Galen E., Zagotta, William N.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083228/
https://www.ncbi.nlm.nih.gov/pubmed/21383006
http://dx.doi.org/10.1074/jbc.M110.214650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083228/
https://www.ncbi.nlm.nih.gov/pubmed/21383006
http://dx.doi.org/10.1074/jbc.M110.214650

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