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Molecular Mechanism Underlying Phosphatidylinositol 4,5-Bisphosphate-induced Inhibition of SpIH Channels
Many ion channels have been shown to be regulated by the membrane signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)). Here, we demonstrate that the binding of PIP(2) to SpIH, a sea urchin hyperpolarization-activated cyclic nucleotide-gated ion channel (HCN), has a dual effect: pot...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083228/ https://www.ncbi.nlm.nih.gov/pubmed/21383006 http://dx.doi.org/10.1074/jbc.M110.214650 |