Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis, whose largest subgroup is characterized by somatic mutations in NPM1, the gene for Nucleophosmin1. These mutations, termed NPM1c, result in cytoplasmic dislocation of Nucleophosmin1 and are associated with distin...

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Detalles Bibliográficos
Autores principales: Vassiliou, George S., Cooper, Jonathan L., Rad, Roland, Li, Juan, Rice, Stephen, Uren, Anthony, Rad, Lena, Ellis, Peter, Andrews, Rob, Banerjee, Ruby, Grove, Carolyn, Wang, Wei, Liu, Pentao, Wright, Penny, Arends, Mark, Bradley, Allan
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084174/
https://www.ncbi.nlm.nih.gov/pubmed/21441929
http://dx.doi.org/10.1038/ng.796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084174/
https://www.ncbi.nlm.nih.gov/pubmed/21441929
http://dx.doi.org/10.1038/ng.796

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