Antibody Engineering Using Phage Display with a Coiled-Coil Heterodimeric Fv Antibody Fragment

A Fab-like antibody binding unit, ccFv, in which a pair of heterodimeric coiled-coil domains was fused to V(H) and V(L) for Fv stabilization, was constructed for an anti-VEGF antibody. The anti-VEGF ccFv showed the same binding affinity as scFv but significantly improved stability and phage display...

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Detalles Bibliográficos
Autores principales: Wang, Xinwei, Zhong, Pinyu, Luo, Peter P., Wang, Kevin C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084267/
https://www.ncbi.nlm.nih.gov/pubmed/21552519
http://dx.doi.org/10.1371/journal.pone.0019023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084267/
https://www.ncbi.nlm.nih.gov/pubmed/21552519
http://dx.doi.org/10.1371/journal.pone.0019023

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