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Molecular insight into human platelet antigens: structural and evolutionary conservation analyses offer new perspective to immunogenic disorders

BACKGROUND: Human platelet antigens (HPAs) are polymorphisms in platelet membrane glycoproteins (GPs) that can stimulate production of alloantibodies once exposed to foreign platelets (PLTs) with different HPAs. These antibodies can cause neonatal alloimmune thrombocytopenia, posttransfusion purpura...

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Detalles Bibliográficos
Autores principales: Landau, Meytal, Rosenberg, Nurit
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084503/
https://www.ncbi.nlm.nih.gov/pubmed/20804530
http://dx.doi.org/10.1111/j.1537-2995.2010.02862.x