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Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2

β-arrestins are well known for their roles in desensitization and sequestration of G protein–coupled receptors. Unlike β-arrestin1, β-arrestin2 exhibits a predominant cytoplasmic distribution at steady state. However, the mechanism and functional significance underlying the regulation of β-arrestin2...

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Detalles Bibliográficos
Autores principales: Yin, Chenlei, Zhang, Ru, Xu, Yongyu, Chen, Qiuyan, Xie, Xin
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084682/
https://www.ncbi.nlm.nih.gov/pubmed/21389118
http://dx.doi.org/10.1091/mbc.E10-09-0779