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Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2
β-arrestins are well known for their roles in desensitization and sequestration of G protein–coupled receptors. Unlike β-arrestin1, β-arrestin2 exhibits a predominant cytoplasmic distribution at steady state. However, the mechanism and functional significance underlying the regulation of β-arrestin2...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084682/ https://www.ncbi.nlm.nih.gov/pubmed/21389118 http://dx.doi.org/10.1091/mbc.E10-09-0779 |