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Mamld1 Knockdown Reduces Testosterone Production and Cyp17a1 Expression in Mouse Leydig Tumor Cells

BACKGROUND: MAMLD1 is known to be a causative gene for hypospadias. Although previous studies have indicated that MAMLD1 mutations result in hypospadias primarily because of compromised testosterone production around the critical period for fetal sex development, the underlying mechanism(s) remains...

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Detalles Bibliográficos
Autores principales: Nakamura, Michiko, Fukami, Maki, Sugawa, Fumihiro, Miyado, Mami, Nonomura, Katsuya, Ogata, Tsutomu
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084764/
https://www.ncbi.nlm.nih.gov/pubmed/21559465
http://dx.doi.org/10.1371/journal.pone.0019123