Molecular Mode of Action and Role of TP53 in the Sensitivity to the Novel Epothilone Sagopilone (ZK-EPO) in A549 Non-Small Cell Lung Cancer Cells

Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing compound that has shown high in vitro and in vivo activity against a broad range of human tumor models. We analyzed the differential mechanism of action of sagopilone in non-small cell lung cancer cell lines in vitro....

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Detalles Bibliográficos
Autores principales: Winsel, Sebastian, Sommer, Anette, Eschenbrenner, Julia, Mittelstaedt, Kevin, Klar, Ulrich, Hammer, Stefanie, Hoffmann, Jens
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084814/
https://www.ncbi.nlm.nih.gov/pubmed/21559393
http://dx.doi.org/10.1371/journal.pone.0019273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084814/
https://www.ncbi.nlm.nih.gov/pubmed/21559393
http://dx.doi.org/10.1371/journal.pone.0019273

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