Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of motor and cognitive deficits and are associated with the abnormal accumulation of alpha-synuclein (α-syn). This study investigated whether passive immunization with a novel monoclonal α-syn antibody (9E4) against...

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Detalles Bibliográficos
Autores principales: Masliah, Eliezer, Rockenstein, Edward, Mante, Michael, Crews, Leslie, Spencer, Brian, Adame, Anthony, Patrick, Christina, Trejo, Margarita, Ubhi, Kiren, Rohn, Troy T., Mueller-Steiner, Sarah, Seubert, Peter, Barbour, Robin, McConlogue, Lisa, Buttini, Manuel, Games, Dora, Schenk, Dale
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084838/
https://www.ncbi.nlm.nih.gov/pubmed/21559417
http://dx.doi.org/10.1371/journal.pone.0019338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084838/
https://www.ncbi.nlm.nih.gov/pubmed/21559417
http://dx.doi.org/10.1371/journal.pone.0019338

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