Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

BACKGROUND: The co-inhibitory receptor Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) attenuates immune responses and prevent autoimmunity, however, tumors exploit this pathway to evade the host T-cell response. The T-cell co-stimulatory receptor 4-1BB is transiently upregulated on T-cells following acti...

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Detalles Bibliográficos
Autores principales: Curran, Michael A., Kim, Myoungjoo, Montalvo, Welby, Al-Shamkhani, Aymen, Allison, James P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085474/
https://www.ncbi.nlm.nih.gov/pubmed/21559358
http://dx.doi.org/10.1371/journal.pone.0019499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085474/
https://www.ncbi.nlm.nih.gov/pubmed/21559358
http://dx.doi.org/10.1371/journal.pone.0019499

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