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A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and Citrate Buffer
In the current study, the effect of metal ions in combination with buffers (citrate, acetate, pH 4.5) on the stability of aqueous solutions of oxytocin was investigated. Both monovalent metal ions (Na(+) and K(+)) and divalent metal ions (Ca(2+), Mg(2+), and Zn(2+)) were tested all as chloride salts...
Autores principales: | Avanti, Christina, Amorij, Jean-Pierre, Setyaningsih, Dewi, Hawe, Andrea, Jiskoot, Wim, Visser, Jan, Kedrov, Alexej, Driessen, Arnold J. M., Hinrichs, Wouter L. J., Frijlink, Henderik W. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer US
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085697/ https://www.ncbi.nlm.nih.gov/pubmed/21448747 http://dx.doi.org/10.1208/s12248-011-9268-7 |
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