Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors origina...

Descripción completa

Detalles Bibliográficos
Autores principales: Ang, Kenny K. H., Ratnam, Joseline, Gut, Jiri, Legac, Jennifer, Hansell, Elizabeth, Mackey, Zachary B., Skrzypczynska, Katarzyna M., Debnath, Anjan, Engel, Juan C., Rosenthal, Philip J., McKerrow, James H., Arkin, Michelle R., Renslo, Adam R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086806/
https://www.ncbi.nlm.nih.gov/pubmed/21572521
http://dx.doi.org/10.1371/journal.pntd.0001023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086806/
https://www.ncbi.nlm.nih.gov/pubmed/21572521
http://dx.doi.org/10.1371/journal.pntd.0001023

Ejemplares similares