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Using mechanistic Bayesian networks to identify downstream targets of the Sonic Hedgehog pathway

BACKGROUND: The topology of a biological pathway provides clues as to how a pathway operates, but rationally using this topology information with observed gene expression data remains a challenge. RESULTS: We introduce a new general-purpose analytic method called Mechanistic Bayesian Networks (MBNs)...

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Detalles Bibliográficos
Autores principales: Shah, Abhik, Tenzen, Toyoaki, McMahon, Andrew P, Woolf, Peter J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087349/
https://www.ncbi.nlm.nih.gov/pubmed/20021670
http://dx.doi.org/10.1186/1471-2105-10-433