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Using mechanistic Bayesian networks to identify downstream targets of the Sonic Hedgehog pathway
BACKGROUND: The topology of a biological pathway provides clues as to how a pathway operates, but rationally using this topology information with observed gene expression data remains a challenge. RESULTS: We introduce a new general-purpose analytic method called Mechanistic Bayesian Networks (MBNs)...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087349/ https://www.ncbi.nlm.nih.gov/pubmed/20021670 http://dx.doi.org/10.1186/1471-2105-10-433 |