Automated synthesis of an (18)F-labelled pyridine-based alkylating agent for high yield oligonucleotide conjugation

Alkylating agents have been shown to be very promising for the radiolabelling of oligonucleotides with fluorine-18. In this report we describe the fully automated synthesis of 2-bromo-N-[3-(2-[(18)F]fluoropyridin-3-yloxy)propyl]acetamide ([(18)F]FPyBrA) utilizing a modular synthesis unit. Reaction c...

Descripción completa

Detalles Bibliográficos
Autores principales: von Guggenberg, Elisabeth, Sader, Jayden A., Wilson, John S., Shahhosseini, Soraya, Koslowsky, Ingrid, Wuest, Frank, Mercer, John R.
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087498/
https://www.ncbi.nlm.nih.gov/pubmed/19446463
http://dx.doi.org/10.1016/j.apradiso.2009.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087498/
https://www.ncbi.nlm.nih.gov/pubmed/19446463
http://dx.doi.org/10.1016/j.apradiso.2009.04.004

Ejemplares similares