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Automated synthesis of an (18)F-labelled pyridine-based alkylating agent for high yield oligonucleotide conjugation
Alkylating agents have been shown to be very promising for the radiolabelling of oligonucleotides with fluorine-18. In this report we describe the fully automated synthesis of 2-bromo-N-[3-(2-[(18)F]fluoropyridin-3-yloxy)propyl]acetamide ([(18)F]FPyBrA) utilizing a modular synthesis unit. Reaction c...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087498/ https://www.ncbi.nlm.nih.gov/pubmed/19446463 http://dx.doi.org/10.1016/j.apradiso.2009.04.004 |