Cargando…
Munc13 Mediates the Transition from the Closed Syntaxin–Munc18 complex to the SNARE complex
During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an open conformation within the highly stable SNARE complex. Control of this conformational transition is key for brain...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087822/ https://www.ncbi.nlm.nih.gov/pubmed/21499244 http://dx.doi.org/10.1038/nsmb.2047 |