DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

The vitamin D receptor (VDR) functions as an obligate heterodimer with the retinoid X receptor (RXR). These nuclear receptors (NRs) are multidomain proteins and it is unclear how various domains interact with one another within the NR heterodimer. Here we show that binding of intact heterodimer to D...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Chalmers, Michael J., Stayrook, Keith R., Burris, Lorri L., Wang, Yongjun, Busby, Scott A., Pascal, Bruce D., Garcia-Ordonez, Ruben D, Bruning, John B., Istrate, Monica A, Kojetin, Douglas J., Dodge, Jeffrey A., Burris, Thomas P., Griffin, Patrick R.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087838/
https://www.ncbi.nlm.nih.gov/pubmed/21478866
http://dx.doi.org/10.1038/nsmb.2046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087838/
https://www.ncbi.nlm.nih.gov/pubmed/21478866
http://dx.doi.org/10.1038/nsmb.2046

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