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The client protein p53 forms a molten globule-like state in the presence of Hsp90
It is not currently known in what state (folded, unfolded, alternatively folded) client proteins interact with chaperone Hsp90. We show that one client, the p53 DNA-binding domain, undergoes a structural change in the presence of Hsp90 to adopt a molten globule-like state. Addition of one- and two-d...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087862/ https://www.ncbi.nlm.nih.gov/pubmed/21460846 http://dx.doi.org/10.1038/nsmb.2045 |