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A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS

To better understand the detection and management of iron overload in transfusion-dependent patients with myelodysplastic syndromes (MDS), a 15-min web- or paper-based survey was conducted among 338 European physicians from 27 countries. Respondents had a mean of 18 years of clinical experience. For...

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Detalles Bibliográficos
Autores principales: Giagounidis, Aristoteles, Leto di Priolo, Susanna, Ille, Susanne, Fenaux, Pierre
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087870/
https://www.ncbi.nlm.nih.gov/pubmed/21327403
http://dx.doi.org/10.1007/s00277-011-1181-8
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author Giagounidis, Aristoteles
Leto di Priolo, Susanna
Ille, Susanne
Fenaux, Pierre
author_facet Giagounidis, Aristoteles
Leto di Priolo, Susanna
Ille, Susanne
Fenaux, Pierre
author_sort Giagounidis, Aristoteles
collection PubMed
description To better understand the detection and management of iron overload in transfusion-dependent patients with myelodysplastic syndromes (MDS), a 15-min web- or paper-based survey was conducted among 338 European physicians from 27 countries. Respondents had a mean of 18 years of clinical experience. Forty-six percent and 27% of physicians noted that detecting and treating iron overload were either “very important” or “important,” respectively. The main reason for not actively exploring iron overload was related to poor patient prognosis, while the main reasons for not initiating iron chelation therapy were poor patient prognosis and older patient age. Thirty-seven percent and 31% of physicians believed that treating iron overload in these patients was “very important” or “important,” respectively. Ninety percent of physicians prescribed iron chelation therapy, and 38% of transfusion-dependent patients received iron chelation therapy. The key reasons for not initiating iron chelation therapy were related to poor patient prognosis (72%), patient age ≥85 years (50%), and comorbidities (34%). The views of these experienced MDS physicians reflect available international MDS treatment guidelines.
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spelling pubmed-30878702011-06-06 A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS Giagounidis, Aristoteles Leto di Priolo, Susanna Ille, Susanne Fenaux, Pierre Ann Hematol Original Article To better understand the detection and management of iron overload in transfusion-dependent patients with myelodysplastic syndromes (MDS), a 15-min web- or paper-based survey was conducted among 338 European physicians from 27 countries. Respondents had a mean of 18 years of clinical experience. Forty-six percent and 27% of physicians noted that detecting and treating iron overload were either “very important” or “important,” respectively. The main reason for not actively exploring iron overload was related to poor patient prognosis, while the main reasons for not initiating iron chelation therapy were poor patient prognosis and older patient age. Thirty-seven percent and 31% of physicians believed that treating iron overload in these patients was “very important” or “important,” respectively. Ninety percent of physicians prescribed iron chelation therapy, and 38% of transfusion-dependent patients received iron chelation therapy. The key reasons for not initiating iron chelation therapy were related to poor patient prognosis (72%), patient age ≥85 years (50%), and comorbidities (34%). The views of these experienced MDS physicians reflect available international MDS treatment guidelines. Springer-Verlag 2011-02-16 2011 /pmc/articles/PMC3087870/ /pubmed/21327403 http://dx.doi.org/10.1007/s00277-011-1181-8 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Giagounidis, Aristoteles
Leto di Priolo, Susanna
Ille, Susanne
Fenaux, Pierre
A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title_full A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title_fullStr A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title_full_unstemmed A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title_short A European survey on the detection and management of iron overload in transfusion-dependent patients with MDS
title_sort european survey on the detection and management of iron overload in transfusion-dependent patients with mds
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087870/
https://www.ncbi.nlm.nih.gov/pubmed/21327403
http://dx.doi.org/10.1007/s00277-011-1181-8
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