IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway

BACKGROUND: Glucose restriction in cells increases the AMP/ATP ratio (energetic stress), which activates the AMPK/p53 pathway. Depending upon the energetic stress levels, cells undergo either autophagy or cell death. Given that the activated p53 induces the expression of IFI16 protein, we investigat...

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Detalles Bibliográficos
Autores principales: Duan, Xin, Ponomareva, Larissa, Veeranki, Sudhakar, Choubey, Divaker
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088686/
https://www.ncbi.nlm.nih.gov/pubmed/21573174
http://dx.doi.org/10.1371/journal.pone.0019532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088686/
https://www.ncbi.nlm.nih.gov/pubmed/21573174
http://dx.doi.org/10.1371/journal.pone.0019532

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