Histidine-Mediated pH-Sensitive Regulation of M-Ficolin:GlcNAc Binding Activity in Innate Immunity Examined by Molecular Dynamics Simulations

BACKGROUND: M-ficolin, a pathogen recognition molecule in the innate immune system, binds sugar residues including N-acetyl-D-glucosamine (GlcNAc), which is displayed on invading microbes and on apoptotic cells. The cis and trans Asp282-Cys283 peptide bond in the M-ficolin, which was found to occur...

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Detalles Bibliográficos
Autores principales: Yang, Lifeng, Zhang, Jing, Ho, Bow, Ding, Jeak Ling
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088710/
https://www.ncbi.nlm.nih.gov/pubmed/21573188
http://dx.doi.org/10.1371/journal.pone.0019647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088710/
https://www.ncbi.nlm.nih.gov/pubmed/21573188
http://dx.doi.org/10.1371/journal.pone.0019647

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