Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium

Quinolones inhibit bacterial type II DNA topoisomerases (e.g. DNA gyrase) and are among the most important antibiotics in current use. However, their efficacy is now being threatened by various plasmid-mediated resistance determinants. Of these, the pentapeptide repeat-containing (PRP) Qnr proteins...

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Detalles Bibliográficos
Autores principales: Xiong, Xiaoli, Bromley, Elizabeth H. C., Oelschlaeger, Peter, Woolfson, Derek N., Spencer, James
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089455/
https://www.ncbi.nlm.nih.gov/pubmed/21227918
http://dx.doi.org/10.1093/nar/gkq1296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089455/
https://www.ncbi.nlm.nih.gov/pubmed/21227918
http://dx.doi.org/10.1093/nar/gkq1296

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