Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

The CAG repeat expansions that occur in translated regions of specific genes can cause human genetic disorders known as polyglutamine (poly-Q)-triggered diseases. Huntington’s disease and spinobulbar muscular atrophy (SBMA) are examples of these diseases in which underlying mutations are localized n...

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Detalles Bibliográficos
Autores principales: de Mezer, Mateusz, Wojciechowska, Marzena, Napierala, Marek, Sobczak, Krzysztof, Krzyzosiak, Wlodzimierz J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089464/
https://www.ncbi.nlm.nih.gov/pubmed/21247881
http://dx.doi.org/10.1093/nar/gkq1323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089464/
https://www.ncbi.nlm.nih.gov/pubmed/21247881
http://dx.doi.org/10.1093/nar/gkq1323

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