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Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase
Methylation of the five position of cytosine in DNA plays important roles in epigenetic regulation in diverse organisms including humans. The transfer of methyl groups from the cofactor S-adenosyl-l-methionine is carried out by methyltransferase enzymes. Using the paradigm bacterial methyltransferas...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089467/ https://www.ncbi.nlm.nih.gov/pubmed/21245034 http://dx.doi.org/10.1093/nar/gkq1329 |