Merkel Cell Polyomavirus Large T Antigen Disrupts Lysosome Clustering by Translocating Human Vam6p from the Cytoplasm to the Nucleus

Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVa...

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Detalles Bibliográficos
Autores principales: Liu, Xi, Hein, Jennifer, Richardson, Simon C. W., Basse, Per H., Toptan, Tuna, Moore, Patrick S., Gjoerup, Ole V., Chang, Yuan
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089552/
https://www.ncbi.nlm.nih.gov/pubmed/21454559
http://dx.doi.org/10.1074/jbc.M110.192856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089552/
https://www.ncbi.nlm.nih.gov/pubmed/21454559
http://dx.doi.org/10.1074/jbc.M110.192856

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