DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires processing of broken ends. For repair to commence, the DSB must first be resected to generate a 3'-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA strand exchange protein, Rad51(1...

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Detalles Bibliográficos
Autores principales: Cejka, Petr, Cannavo, Elda, Polaczek, Piotr, Masuda-Sasa, Taro, Pokharel, Subhash, Campbell, Judith L., Kowalczykowski, Stephen C.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089589/
https://www.ncbi.nlm.nih.gov/pubmed/20811461
http://dx.doi.org/10.1038/nature09355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089589/
https://www.ncbi.nlm.nih.gov/pubmed/20811461
http://dx.doi.org/10.1038/nature09355

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