Cargando…

DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires processing of broken ends. For repair to commence, the DSB must first be resected to generate a 3'-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA strand exchange protein, Rad51(1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cejka, Petr, Cannavo, Elda, Polaczek, Piotr, Masuda-Sasa, Taro, Pokharel, Subhash, Campbell, Judith L., Kowalczykowski, Stephen C.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089589/ https://www.ncbi.nlm.nih.gov/pubmed/20811461 http://dx.doi.org/10.1038/nature09355

Ejemplares similares

Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection
por: Reginato, Giordano, et al.
Publicado: (2017)

The Mre11-Rad50-Xrs2 Complex Is Required for Yeast DNA Postreplication Repair
por: Ball, Lindsay G., et al.
Publicado: (2014)

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3
por: Cejka, Petr, et al.
Publicado: (2010)

Plasticity of the Mre11–Rad50–Xrs2–Sae2 nuclease ensemble in the processing of DNA-bound obstacles
por: Wang, Weibin, et al.
Publicado: (2017)

Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks
por: Nicolette, Matthew L., et al.
Publicado: (2010)

A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair
por: Steininger, Sylvia, et al.
Publicado: (2010)

S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex
por: Chen, Yu-Jie, et al.
Publicado: (2016)

Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair
por: Budd, Martin E., et al.
Publicado: (2009)

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA
por: Bell, Jason C., et al.
Publicado: (2023)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

Dynamic Properties of the DNA Damage Response Mre11/Rad50 Complex
por: Vertemara, Jacopo, et al.
Publicado: (2023)

An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA
por: Haseltine, Cynthia A., et al.
Publicado: (2009)

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae
por: Campos-Doerfler, Lillian, et al.
Publicado: (2018)

BLM and RMI1 Alleviate RPA Inhibition of TopoIIIα Decatenase Activity
por: Yang, Jay, et al.
Publicado: (2012)

Force regulated dynamics of RPA on a DNA fork
por: Kemmerich, Felix E., et al.
Publicado: (2016)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates
por: Bonner, Jacob N., et al.
Publicado: (2016)

Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
por: Agashe, Sumedha, et al.
Publicado: (2021)

ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
por: Ding, Jiawei, et al.
Publicado: (2023)

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair
por: Williams, Gareth J., et al.
Publicado: (2011)

DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcanii
por: Delmas, Stéphane, et al.
Publicado: (2013)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
por: Bian, Lei, et al.
Publicado: (2019)

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
por: Ma, Chu Jian, et al.
Publicado: (2017)

Multifaceted regulation of the sumoylation of the Sgs1 DNA helicase
por: Li, Shibai, et al.
Publicado: (2022)

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
por: Jazayeri, Ali, et al.
Publicado: (2008)

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis
por: Taylor, Elaine M., et al.
Publicado: (2010)

Mre11-Rad50–dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1
por: Limbo, Oliver, et al.
Publicado: (2018)

Rad51 protects nascent DNA from Mre11 dependent degradation and promotes continuous DNA synthesis
por: Hashimoto, Yoshitami, et al.
Publicado: (2010)

Distinct RPA domains promote recruitment and the helicase-nuclease activities of Dna2
por: Acharya, Ananya, et al.
Publicado: (2021)

Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
por: Bakx, Julia A. M., et al.
Publicado: (2022)

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex
por: Canny, Marella D, et al.
Publicado: (2022)

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection
por: Daley, James M., et al.
Publicado: (2014)

Mre11-Rad50 Promotes Rapid Repair of DNA Damage in the Polyploid Archaeon Haloferax volcanii by Restraining Homologous Recombination
por: Delmas, Stéphane, et al.
Publicado: (2009)

Physical and functional interplay between PCNA DNA clamp and Mre11–Rad50 complex from the archaeon Pyrococcus furiosus
por: Hogrel, Gaëlle, et al.
Publicado: (2018)

Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopy
por: Zabolotnaya, Ekaterina, et al.
Publicado: (2020)

Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients
por: Djuzenova, C, et al.
Publicado: (2004)

The Rad50 Coiled Coil Domain is indispensable for Mre11 complex functions
por: Hohl, Marcel, et al.
Publicado: (2011)

Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
por: Ferrari, Matteo, et al.
Publicado: (2020)

The bacterial Mre11–Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions
por: Saathoff, Jan-Hinnerk, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_htp1mki9fqkr13dqu1kuo3go0f