β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. The DYRK1A gene is located within the Down Syndrome Critical Region (DSCR) on chromosome 21. We and others have implicated DYRK1A in the phosphorylatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Frost, Danielle, Meechoovet, Bessie, Wang, Tong, Gately, Stephen, Giorgetti, Marco, Shcherbakova, Irina, Dunckley, Travis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089604/
https://www.ncbi.nlm.nih.gov/pubmed/21573099
http://dx.doi.org/10.1371/journal.pone.0019264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089604/
https://www.ncbi.nlm.nih.gov/pubmed/21573099
http://dx.doi.org/10.1371/journal.pone.0019264

Ejemplares similares