A vital role for IL-2 trans-presentation in DC-mediated T cell activation in humans as revealed by daclizumab therapy

While previous studies have described CD25 expression on mature dendritic cells (mDCs) and their production of IL-2, it remains unclear how these molecules participate in the activation of T cells. In search of the mechanisms by which daclizumab, a humanized monoclonal antibody against CD25, inhibit...

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Detalles Bibliográficos
Autores principales: Wuest, Simone C., Edwan, Jehad, Martin, Jayne F., Han, Sungpil, Perry, Justin S.A., Cartagena, Casandra M., Matsuura, Eiji, Maric, Dragan, Waldmann, Thomas A., Bielekova, Bibiana
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089658/
https://www.ncbi.nlm.nih.gov/pubmed/21532597
http://dx.doi.org/10.1038/nm.2365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089658/
https://www.ncbi.nlm.nih.gov/pubmed/21532597
http://dx.doi.org/10.1038/nm.2365

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