The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site

The human G1m1 allotype comprises two amino acids, D12 and L14, in the CH3 domain of IGHG1. Although the G1m1 allotype is prevalent in human populations, ∼40% of Caucasiods are homozygous for the nG1m1 allotype corresponding to E12 and M14. Peptides derived from the G1m1 region were tested for their...

Descripción completa

Detalles Bibliográficos
Autores principales: Stickler, M M, Reddy, A, Xiong, J M, Hinton, P R, DuBridge, R, Harding, F A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089737/
https://www.ncbi.nlm.nih.gov/pubmed/21326320
http://dx.doi.org/10.1038/gene.2010.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089737/
https://www.ncbi.nlm.nih.gov/pubmed/21326320
http://dx.doi.org/10.1038/gene.2010.68

Ejemplares similares