LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway

Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apopt...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasegawa, H, Yamada, Y, Tsukasaki, K, Mori, N, Tsuruda, K, Sasaki, D, Usui, T, Osaka, A, Atogami, S, Ishikawa, C, Machijima, Y, Sawada, S, Hayashi, T, Miyazaki, Y, Kamihira, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089964/
https://www.ncbi.nlm.nih.gov/pubmed/21242994
http://dx.doi.org/10.1038/leu.2010.315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089964/
https://www.ncbi.nlm.nih.gov/pubmed/21242994
http://dx.doi.org/10.1038/leu.2010.315

Ejemplares similares