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LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway

Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apopt...

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Detalles Bibliográficos
Autores principales:	Hasegawa, H, Yamada, Y, Tsukasaki, K, Mori, N, Tsuruda, K, Sasaki, D, Usui, T, Osaka, A, Atogami, S, Ishikawa, C, Machijima, Y, Sawada, S, Hayashi, T, Miyazaki, Y, Kamihira, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089964/ https://www.ncbi.nlm.nih.gov/pubmed/21242994 http://dx.doi.org/10.1038/leu.2010.315

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