USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair. We s...

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Detalles Bibliográficos
Autores principales: Guervilly, Jean-Hugues, Renaud, Emilie, Takata, Minoru, Rosselli, Filippo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090195/
https://www.ncbi.nlm.nih.gov/pubmed/21389083
http://dx.doi.org/10.1093/hmg/ddr103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090195/
https://www.ncbi.nlm.nih.gov/pubmed/21389083
http://dx.doi.org/10.1093/hmg/ddr103

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