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USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
The maintenance of genetic stability depends on the fine-tuned initiation and termination of pathways involved in cell cycle checkpoints and DNA repair. Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair. We s...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090195/ https://www.ncbi.nlm.nih.gov/pubmed/21389083 http://dx.doi.org/10.1093/hmg/ddr103 |