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Lysosomotropic agents as HCV entry inhibitors

HCV has two envelop proteins named as E1 and E2 which play an important role in cell entry through two main pathways: direct fusion at the plasma membrane and receptor-mediated endocytosis. Fusion of the HCV envelope proteins is triggered by low pH within the endosome. Lysosomotropic agents (LA) suc...

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Detalles Bibliográficos
Autores principales: Ashfaq, Usman A, Javed, Tariq, Rehman, Sidra, Nawaz, Zafar, Riazuddin, Sheikh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090357/
https://www.ncbi.nlm.nih.gov/pubmed/21481279
http://dx.doi.org/10.1186/1743-422X-8-163