Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, a...

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Detalles Bibliográficos
Autores principales: Lo, Anthony T. S., Salam, Noeris K., Hibbs, David E., Rutledge, Peter J., Todd, Matthew H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090394/
https://www.ncbi.nlm.nih.gov/pubmed/21573061
http://dx.doi.org/10.1371/journal.pone.0017446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090394/
https://www.ncbi.nlm.nih.gov/pubmed/21573061
http://dx.doi.org/10.1371/journal.pone.0017446

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