Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, a...

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Autores principales: Lo, Anthony T. S., Salam, Noeris K., Hibbs, David E., Rutledge, Peter J., Todd, Matthew H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090394/
https://www.ncbi.nlm.nih.gov/pubmed/21573061
http://dx.doi.org/10.1371/journal.pone.0017446
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author Lo, Anthony T. S.
Salam, Noeris K.
Hibbs, David E.
Rutledge, Peter J.
Todd, Matthew H.
author_facet Lo, Anthony T. S.
Salam, Noeris K.
Hibbs, David E.
Rutledge, Peter J.
Todd, Matthew H.
author_sort Lo, Anthony T. S.
collection PubMed
description Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.
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spelling pubmed-30903942011-05-13 Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal Lo, Anthony T. S. Salam, Noeris K. Hibbs, David E. Rutledge, Peter J. Todd, Matthew H. PLoS One Research Article Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail. Public Library of Science 2011-05-09 /pmc/articles/PMC3090394/ /pubmed/21573061 http://dx.doi.org/10.1371/journal.pone.0017446 Text en Lo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lo, Anthony T. S.
Salam, Noeris K.
Hibbs, David E.
Rutledge, Peter J.
Todd, Matthew H.
Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title_full Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title_fullStr Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title_full_unstemmed Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title_short Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
title_sort polyamide-scorpion cyclam lexitropsins selectively bind at-rich dna independently of the nature of the coordinated metal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090394/
https://www.ncbi.nlm.nih.gov/pubmed/21573061
http://dx.doi.org/10.1371/journal.pone.0017446
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