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A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment

RATIONALE: The nonselective muscarinic antagonist scopolamine hydrobromide (SCOP) is employed as the gold standard for inducing memory impairments in healthy humans and animals. However, its use remains controversial due to the wide spectrum of behavioral effects of this drug. OBJECTIVE: The present...

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Detalles Bibliográficos
Autores principales: Klinkenberg, Inge, Blokland, Arjan
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090581/
https://www.ncbi.nlm.nih.gov/pubmed/21336581
http://dx.doi.org/10.1007/s00213-011-2171-1