Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased lev...

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Detalles Bibliográficos
Autores principales: Hwang, Ara B., Lee, Seung-Jae
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091523/
https://www.ncbi.nlm.nih.gov/pubmed/21389351
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author Hwang, Ara B.
Lee, Seung-Jae
author_facet Hwang, Ara B.
Lee, Seung-Jae
author_sort Hwang, Ara B.
collection PubMed
description A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration.
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spelling pubmed-30915232011-05-12 Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection Hwang, Ara B. Lee, Seung-Jae Aging (Albany NY) Research Perspective A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this longevity. In this research perspective, we discuss our findings and recent advances regarding the roles of ROS and HIF-1 in aging, focusing on the longevity caused by reduced respiration. Impact Journals LLC 2011-03-06 /pmc/articles/PMC3091523/ /pubmed/21389351 Text en Copyright: © 2011 Hwang and Lee http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Hwang, Ara B.
Lee, Seung-Jae
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title_full Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title_fullStr Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title_full_unstemmed Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title_short Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
title_sort regulation of life span by mitochondrial respiration: the hif-1 and ros connection
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091523/
https://www.ncbi.nlm.nih.gov/pubmed/21389351
work_keys_str_mv AT hwangarab regulationoflifespanbymitochondrialrespirationthehif1androsconnection
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