Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

BACKGROUND: Cellular senescence is a major barrier to tumour progression, though its role in pathogenesis of cancer and other diseases is poorly understood in vivo. Improved understanding of the degree to which latent senescence signalling persists in tumours might identify intervention strategies t...

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Detalles Bibliográficos
Autores principales: Lafferty-Whyte, Kyle, Bilsland, Alan, Cairney, Claire J, Hanley, Lorna, Jamieson, Nigel B, Zaffaroni, Nadia, Oien, Karin A, Burns, Sharon, Roffey, Jon, Boyd, Susan M, Keith, W Nicol
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091681/
https://www.ncbi.nlm.nih.gov/pubmed/20920304
http://dx.doi.org/10.1186/1471-2164-11-532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091681/
https://www.ncbi.nlm.nih.gov/pubmed/20920304
http://dx.doi.org/10.1186/1471-2164-11-532

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