Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

BACKGROUND: In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression. In particular, the extent to which alternative splicing is coupled to NMD and the roles of NMD in regulating uORF containing transcripts have been...

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Detalles Bibliográficos
Autores principales: McGlincy, Nicholas J, Tan, Lit-Yeen, Paul, Nicodeme, Zavolan, Mihaela, Lilley, Kathryn S, Smith, Christopher WJ
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091714/
https://www.ncbi.nlm.nih.gov/pubmed/20946641
http://dx.doi.org/10.1186/1471-2164-11-565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091714/
https://www.ncbi.nlm.nih.gov/pubmed/20946641
http://dx.doi.org/10.1186/1471-2164-11-565

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