A Novel Structural Framework for α(1A/D)-Adrenoceptor Selective Antagonists Identified Using Subtype Selective Pharmacophores

In this study four and five-feature pharmacophores for selective antagonists at each of the three α(1)-adrenoceptor (AR) subtypes were used to identify novel α(1)-AR subtype selective compounds in the National Cancer Institute and Tripos LeadQuest databases. 12 compounds were selected, based on dive...

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Detalles Bibliográficos
Autores principales: Stoddart, Emily S., Senadheera, Sevvandi, MacDougall, Iain J. A., Griffith, Renate, Finch, Angela M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091868/
https://www.ncbi.nlm.nih.gov/pubmed/21572949
http://dx.doi.org/10.1371/journal.pone.0019695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091868/
https://www.ncbi.nlm.nih.gov/pubmed/21572949
http://dx.doi.org/10.1371/journal.pone.0019695

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