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Antisense-Mediated Knockdown of Na(V)1.8, but Not Na(V)1.9, Generates Inhibitory Effects on Complete Freund's Adjuvant-Induced Inflammatory Pain in Rat

Tetrodotoxin-resistant (TTX-R) sodium channels Na(V)1.8 and Na(V)1.9 in sensory neurons were known as key pain modulators. Comparing with the widely reported Na(V)1.8, roles of Na(V)1.9 on inflammatory pain are poorly studied by antisense-induced specific gene knockdown. Here, we used molecular, ele...

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Detalles Bibliográficos
Autores principales: Yu, Yao-Qing, Zhao, Feng, Guan, Su-Min, Chen, Jun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091880/
https://www.ncbi.nlm.nih.gov/pubmed/21572961
http://dx.doi.org/10.1371/journal.pone.0019865