No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight

OBJECTIVE: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepine...

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Detalles Bibliográficos
Autores principales: Smith, Daniel L., Robertson, Henry, Desmond, Renee, Nagy, Tim R., Allison, David B.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091992/
https://www.ncbi.nlm.nih.gov/pubmed/21079617
http://dx.doi.org/10.1038/ijo.2010.247
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author Smith, Daniel L.
Robertson, Henry
Desmond, Renee
Nagy, Tim R.
Allison, David B.
author_facet Smith, Daniel L.
Robertson, Henry
Desmond, Renee
Nagy, Tim R.
Allison, David B.
author_sort Smith, Daniel L.
collection PubMed
description OBJECTIVE: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor. RESULTS & CONCLUSION: Using data from a two-year toxicology study of sibutramine in CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared to controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate.
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spelling pubmed-30919922011-11-01 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight Smith, Daniel L. Robertson, Henry Desmond, Renee Nagy, Tim R. Allison, David B. Int J Obes (Lond) Article OBJECTIVE: The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor. RESULTS & CONCLUSION: Using data from a two-year toxicology study of sibutramine in CD rats and CD-1 mice, despite a dose-dependent reduction in food intake and body weight in rats compared to controls, and a body weight reduction in mice at the highest dose, there was no compelling evidence for reductions in mortality rate. 2010-11-16 2011-05 /pmc/articles/PMC3091992/ /pubmed/21079617 http://dx.doi.org/10.1038/ijo.2010.247 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Smith, Daniel L.
Robertson, Henry
Desmond, Renee
Nagy, Tim R.
Allison, David B.
No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title_full No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title_fullStr No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title_full_unstemmed No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title_short No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
title_sort no compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091992/
https://www.ncbi.nlm.nih.gov/pubmed/21079617
http://dx.doi.org/10.1038/ijo.2010.247
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