Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells

Mice and rats lacking the guanosine nucleotide-binding protein Gimap5 exhibit peripheral T cell lymphopenia, and Gimap5 can bind to Bcl-2. We show that Gimap5-deficient mice showed progressive multilineage failure of bone marrow and hematopoiesis. Compared with wild-type counterparts, Gimap5-deficie...

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Detalles Bibliográficos
Autores principales: Chen, Yuhong, Yu, Mei, Dai, Xuezhi, Zogg, Mark, Wen, Renren, Weiler, Hartmut, Wang, Demin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092340/
https://www.ncbi.nlm.nih.gov/pubmed/21502331
http://dx.doi.org/10.1084/jem.20101192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092340/
https://www.ncbi.nlm.nih.gov/pubmed/21502331
http://dx.doi.org/10.1084/jem.20101192

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